Synthesis and analgesic activity of octahydro-2H-chromenols, derivatives of aliphatic ketones
- Авторы: Il’ina I.1,2, Korchagina D.1, Morozova E.1, Tolstikova T.1, Volcho K.1,2, Salakhutdinov N.1,2
-
Учреждения:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Выпуск: Том 68, № 5 (2019)
- Страницы: 1061-1066
- Раздел: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243381
- DOI: https://doi.org/10.1007/s11172-019-2520-5
- ID: 243381
Цитировать
Аннотация
A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol. A condensation product of (—)-isopulegol with the monoterpene ketone l-menthone was synthesized for the first time. The synthesized heterocycles were tested for analgesic activity and compounds with high analgesic activity in the in vivo tests were identified.
Об авторах
I. Il’ina
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: volcho@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090; 1 ul. Pirogova, Novosibirsk, 630090
D. Korchagina
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
E. Morozova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
T. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Email: volcho@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090
K. Volcho
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk National Research State University
Автор, ответственный за переписку.
Email: volcho@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090; 1 ul. Pirogova, Novosibirsk, 630090
N. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: volcho@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrentieva, Novosibirsk, 630090; 1 ul. Pirogova, Novosibirsk, 630090