Email this article The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancer
- Authors: Zakharova G.S.1, Poloznikov A.A.2, Astakhova L.A.1, Raigorodskaya M.P.1, Khesina Z.B.1,3, Fomicheva K.A.2, Buryak A.K.3, Alekseev B.Y.2
-
Affiliations:
- SRC Bioclinicum Ltd
- National Medical Research Center of Radiology
- A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
- Issue: Vol 67, No 12 (2018)
- Pages: 2307-2315
- Section: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243235
- DOI: https://doi.org/10.1007/s11172-018-2374-2
- ID: 243235
Cite item
Open Access
Access granted
Subscription Access
Abstract
The paper addresses the effect of a new fatty acid elongase 6 (ELOVL6) inhibitor on the migration of breast cancer cells (estrogen receptor positive MCF7 cells and estrogen receptor negative MDA-MB-231 cells) and expression of genes associated with the epithelial-mesenchymal transition, the first stage of tumor metastasis. It was shown that inhibition of the synthesis of C18 fatty acids does not change the migration activity or expression of transcription factors regulating the epithelial-mesenchymal transition. At the same time, the inhibition of ELOVL6 resulted in overexpression of genes associated with breast cancer development and metastasis in vivo (EGFR, CASP4 and VEGFA).
About the authors
G. S. Zakharova
SRC Bioclinicum Ltd
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088
A. A. Poloznikov
National Medical Research Center of Radiology
Author for correspondence.
Email: andrey.poloznikov@nmicr.ru
Russian Federation, 4 ul. Koroleva, Obninsk, 249036
L. A. Astakhova
SRC Bioclinicum Ltd
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088
M. P. Raigorodskaya
SRC Bioclinicum Ltd
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088
Z. B. Khesina
SRC Bioclinicum Ltd; A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088; Build. 4, 31 Leninsky prosp., Moscow, 119071
K. A. Fomicheva
National Medical Research Center of Radiology
Email: andrey.poloznikov@nmicr.ru
Russian Federation, 4 ul. Koroleva, Obninsk, 249036
A. K. Buryak
A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: andrey.poloznikov@nmicr.ru
Russian Federation, Build. 4, 31 Leninsky prosp., Moscow, 119071
B. Ya. Alekseev
National Medical Research Center of Radiology
Email: andrey.poloznikov@nmicr.ru
Russian Federation, 4 ul. Koroleva, Obninsk, 249036
