The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancer
- 作者: Zakharova G.1, Poloznikov A.2, Astakhova L.1, Raigorodskaya M.1, Khesina Z.1,3, Fomicheva K.2, Buryak A.3, Alekseev B.2
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隶属关系:
- SRC Bioclinicum Ltd
- National Medical Research Center of Radiology
- A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
- 期: 卷 67, 编号 12 (2018)
- 页面: 2307-2315
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243235
- DOI: https://doi.org/10.1007/s11172-018-2374-2
- ID: 243235
如何引用文章
详细
The paper addresses the effect of a new fatty acid elongase 6 (ELOVL6) inhibitor on the migration of breast cancer cells (estrogen receptor positive MCF7 cells and estrogen receptor negative MDA-MB-231 cells) and expression of genes associated with the epithelial-mesenchymal transition, the first stage of tumor metastasis. It was shown that inhibition of the synthesis of C18 fatty acids does not change the migration activity or expression of transcription factors regulating the epithelial-mesenchymal transition. At the same time, the inhibition of ELOVL6 resulted in overexpression of genes associated with breast cancer development and metastasis in vivo (EGFR, CASP4 and VEGFA).
作者简介
G. Zakharova
SRC Bioclinicum Ltd
Email: andrey.poloznikov@nmicr.ru
俄罗斯联邦, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088
A. Poloznikov
National Medical Research Center of Radiology
编辑信件的主要联系方式.
Email: andrey.poloznikov@nmicr.ru
俄罗斯联邦, 4 ul. Koroleva, Obninsk, 249036
L. Astakhova
SRC Bioclinicum Ltd
Email: andrey.poloznikov@nmicr.ru
俄罗斯联邦, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088
M. Raigorodskaya
SRC Bioclinicum Ltd
Email: andrey.poloznikov@nmicr.ru
俄罗斯联邦, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088
Z. Khesina
SRC Bioclinicum Ltd; A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: andrey.poloznikov@nmicr.ru
俄罗斯联邦, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088; Build. 4, 31 Leninsky prosp., Moscow, 119071
K. Fomicheva
National Medical Research Center of Radiology
Email: andrey.poloznikov@nmicr.ru
俄罗斯联邦, 4 ul. Koroleva, Obninsk, 249036
A. Buryak
A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: andrey.poloznikov@nmicr.ru
俄罗斯联邦, Build. 4, 31 Leninsky prosp., Moscow, 119071
B. Alekseev
National Medical Research Center of Radiology
Email: andrey.poloznikov@nmicr.ru
俄罗斯联邦, 4 ul. Koroleva, Obninsk, 249036