Enviar artigo por via de e-mail The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancer
- Autores: Zakharova G.1, Poloznikov A.2, Astakhova L.1, Raigorodskaya M.1, Khesina Z.1,3, Fomicheva K.2, Buryak A.3, Alekseev B.2
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Afiliações:
- SRC Bioclinicum Ltd
- National Medical Research Center of Radiology
- A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
- Edição: Volume 67, Nº 12 (2018)
- Páginas: 2307-2315
- Seção: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243235
- DOI: https://doi.org/10.1007/s11172-018-2374-2
- ID: 243235
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Resumo
The paper addresses the effect of a new fatty acid elongase 6 (ELOVL6) inhibitor on the migration of breast cancer cells (estrogen receptor positive MCF7 cells and estrogen receptor negative MDA-MB-231 cells) and expression of genes associated with the epithelial-mesenchymal transition, the first stage of tumor metastasis. It was shown that inhibition of the synthesis of C18 fatty acids does not change the migration activity or expression of transcription factors regulating the epithelial-mesenchymal transition. At the same time, the inhibition of ELOVL6 resulted in overexpression of genes associated with breast cancer development and metastasis in vivo (EGFR, CASP4 and VEGFA).
Sobre autores
G. Zakharova
SRC Bioclinicum Ltd
Email: andrey.poloznikov@nmicr.ru
Rússia, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088
A. Poloznikov
National Medical Research Center of Radiology
Autor responsável pela correspondência
Email: andrey.poloznikov@nmicr.ru
Rússia, 4 ul. Koroleva, Obninsk, 249036
L. Astakhova
SRC Bioclinicum Ltd
Email: andrey.poloznikov@nmicr.ru
Rússia, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088
M. Raigorodskaya
SRC Bioclinicum Ltd
Email: andrey.poloznikov@nmicr.ru
Rússia, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088
Z. Khesina
SRC Bioclinicum Ltd; A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: andrey.poloznikov@nmicr.ru
Rússia, Build. 85, 2 ul. Ugreshskaya, Moscow, 115088; Build. 4, 31 Leninsky prosp., Moscow, 119071
K. Fomicheva
National Medical Research Center of Radiology
Email: andrey.poloznikov@nmicr.ru
Rússia, 4 ul. Koroleva, Obninsk, 249036
A. Buryak
A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
Email: andrey.poloznikov@nmicr.ru
Rússia, Build. 4, 31 Leninsky prosp., Moscow, 119071
B. Alekseev
National Medical Research Center of Radiology
Email: andrey.poloznikov@nmicr.ru
Rússia, 4 ul. Koroleva, Obninsk, 249036
