Enviar artigo por via de e-mail Peptide Modulators of ASIC Channels of the Sea Anemone Urticina aff. coriacea (Cuvier, 1798) from the Sea of Okhotsk
- Autores: Gladkikh I.N.1, Kvetkina A.N.1, Kostina E.E.2, Kalina R.S.1, Grebnev B.B.1, Koshelev S.G.3, Kozlov S.A.3, Monastyrnaya M.M.1, Kozlovskaya E.P.1
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Afiliações:
- Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
- Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far East Branch, Russian Academy of Sciences
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Edição: Volume 44, Nº 6 (2018)
- Páginas: 458-464
- Seção: Original Papers
- URL: https://journals.rcsi.science/1063-0740/article/view/184281
- DOI: https://doi.org/10.1134/S1063074018060044
- ID: 184281
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Resumo
A search for biologically active peptides has been performed in an aqueous extract of the sea anemone Urticina aff. coriacea (Cuvier, 1798) (Actiniidae) from the Sea of Okhotsk. A separation of the peptides by size-exclusion chromatography and subsequent electrophysiological testing have shown that peptides of three fractions can completely inhibit currents of mammalian ASIC1a channels. The sea anemone Urticina aff. coriacea is believed to be a promising source of novel peptides that interact with ASIC channels.
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Sobre autores
I. Gladkikh
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Autor responsável pela correspondência
Email: irinagladkikh@gmail.com
Rússia, Vladivostok, 690022
A. Kvetkina
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Rússia, Vladivostok, 690022
E. Kostina
Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far East Branch,Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Rússia, Vladivostok, 690041
R. Kalina
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Rússia, Vladivostok, 690022
B. Grebnev
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Rússia, Vladivostok, 690022
S. Koshelev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Rússia, Moscow, 117997
S. Kozlov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Rússia, Moscow, 117997
M. Monastyrnaya
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Rússia, Vladivostok, 690022
E. Kozlovskaya
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Rússia, Vladivostok, 690022
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