Отправить статью по E-mail Peptide Modulators of ASIC Channels of the Sea Anemone Urticina aff. coriacea (Cuvier, 1798) from the Sea of Okhotsk
- Авторы: Gladkikh I.N.1, Kvetkina A.N.1, Kostina E.E.2, Kalina R.S.1, Grebnev B.B.1, Koshelev S.G.3, Kozlov S.A.3, Monastyrnaya M.M.1, Kozlovskaya E.P.1
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Учреждения:
- Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
- Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far East Branch, Russian Academy of Sciences
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Выпуск: Том 44, № 6 (2018)
- Страницы: 458-464
- Раздел: Original Papers
- URL: https://journals.rcsi.science/1063-0740/article/view/184281
- DOI: https://doi.org/10.1134/S1063074018060044
- ID: 184281
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Аннотация
A search for biologically active peptides has been performed in an aqueous extract of the sea anemone Urticina aff. coriacea (Cuvier, 1798) (Actiniidae) from the Sea of Okhotsk. A separation of the peptides by size-exclusion chromatography and subsequent electrophysiological testing have shown that peptides of three fractions can completely inhibit currents of mammalian ASIC1a channels. The sea anemone Urticina aff. coriacea is believed to be a promising source of novel peptides that interact with ASIC channels.
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Об авторах
I. Gladkikh
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: irinagladkikh@gmail.com
Россия, Vladivostok, 690022
A. Kvetkina
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Россия, Vladivostok, 690022
E. Kostina
Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far East Branch,Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Россия, Vladivostok, 690041
R. Kalina
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Россия, Vladivostok, 690022
B. Grebnev
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Россия, Vladivostok, 690022
S. Koshelev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Россия, Moscow, 117997
S. Kozlov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Россия, Moscow, 117997
M. Monastyrnaya
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Россия, Vladivostok, 690022
E. Kozlovskaya
Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences
Email: irinagladkikh@gmail.com
Россия, Vladivostok, 690022
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