Experimental Justification of Approaches to Developing Pathogenetic Means towards the Prevention and Treatment of Early Postradiation Gastrointestinal Disorders
- 作者: Drachev I.1, Legeza V.2, Seleznev A.1, Grebenyuk A.2
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隶属关系:
- State Scientific Research Test Institute of Military Medicine
- Kirov Military Medical Academy
- 期: 卷 46, 编号 11 (2019)
- 页面: 1571-1575
- 栏目: Modification of Radiation Effects
- URL: https://journals.rcsi.science/1062-3590/article/view/183393
- DOI: https://doi.org/10.1134/S1062359019110116
- ID: 183393
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详细
Experiments on dogs have shown that antagonists of receptor types D2 (domperidone, metoclopramide, dimethpramide), 5-HT3 (ondansetron, palonosetron), and NK1 (aprepitant) impair gastrointestinal manifestations of the primary reaction to irradiation (vomiting and diarrhea). Blockers of H2 (cimetidine) and opiate (naloxone) receptors, inhibitors of prostaglandin synthesis (voltaren, indomethacin), and M-cholinolytic methacin have a predominantly antidiarrheal effect. None of the drugs in our trials reduced the severity of early postradiation hypokinesia. The most promising avenue to effectively prevent and treat the main clinical manifestations of the primary reaction to irradiation is assumed to be the development of complex drugs that affect various aspects of pathogenesis.
作者简介
I. Drachev
State Scientific Research Test Institute of Military Medicine
编辑信件的主要联系方式.
Email: dr.ingwar@mail.ru
俄罗斯联邦, St. Petersburg
V. Legeza
Kirov Military Medical Academy
Email: dr.ingwar@mail.ru
俄罗斯联邦, St. Petersburg
A. Seleznev
State Scientific Research Test Institute of Military Medicine
Email: dr.ingwar@mail.ru
俄罗斯联邦, St. Petersburg
A. Grebenyuk
Kirov Military Medical Academy
Email: dr.ingwar@mail.ru
俄罗斯联邦, St. Petersburg