Experimental Justification of Approaches to Developing Pathogenetic Means towards the Prevention and Treatment of Early Postradiation Gastrointestinal Disorders
- Authors: Drachev I.S.1, Legeza V.I.2, Seleznev A.B.1, Grebenyuk A.N.2
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Affiliations:
- State Scientific Research Test Institute of Military Medicine
- Kirov Military Medical Academy
- Issue: Vol 46, No 11 (2019)
- Pages: 1571-1575
- Section: Modification of Radiation Effects
- URL: https://journals.rcsi.science/1062-3590/article/view/183393
- DOI: https://doi.org/10.1134/S1062359019110116
- ID: 183393
Cite item
Abstract
Experiments on dogs have shown that antagonists of receptor types D2 (domperidone, metoclopramide, dimethpramide), 5-HT3 (ondansetron, palonosetron), and NK1 (aprepitant) impair gastrointestinal manifestations of the primary reaction to irradiation (vomiting and diarrhea). Blockers of H2 (cimetidine) and opiate (naloxone) receptors, inhibitors of prostaglandin synthesis (voltaren, indomethacin), and M-cholinolytic methacin have a predominantly antidiarrheal effect. None of the drugs in our trials reduced the severity of early postradiation hypokinesia. The most promising avenue to effectively prevent and treat the main clinical manifestations of the primary reaction to irradiation is assumed to be the development of complex drugs that affect various aspects of pathogenesis.
About the authors
I. S. Drachev
State Scientific Research Test Institute of Military Medicine
Author for correspondence.
Email: dr.ingwar@mail.ru
Russian Federation, St. Petersburg
V. I. Legeza
Kirov Military Medical Academy
Email: dr.ingwar@mail.ru
Russian Federation, St. Petersburg
A. B. Seleznev
State Scientific Research Test Institute of Military Medicine
Email: dr.ingwar@mail.ru
Russian Federation, St. Petersburg
A. N. Grebenyuk
Kirov Military Medical Academy
Email: dr.ingwar@mail.ru
Russian Federation, St. Petersburg