Solid-Contact Potentiometric Sensors for the Determination of Some Cephalosporin Antibiotics in Pharmaceuticals and Oral Fluid
- 作者: Kulapina E.1, Tyutlikova M.1, Kulapina O.2, Dubasova A.1
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隶属关系:
- Chernyshevsky Saratov State University
- Razumovsky State Medical University
- 期: 卷 74, 编号 Suppl 1 (2019)
- 页面: 52-58
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183271
- DOI: https://doi.org/10.1134/S1061934819070128
- ID: 183271
如何引用文章
详细
We developed unmodified and polyaniline-modified solid-contact potentiometric sensors based on organic ion exchangers—tetradecylammonium associates and complex compounds of silver(I) with Cefazolin (Cefotaxime, Cefuroxime). The sensors offer a wide analytical range of cephalosporin antibiotics of 1 × 10–4 (5 × 10–5) to 0.1 M; the limits of detection for antibiotics are n × 10–5 M. The introduction of polyaniline shortens the time for reaching the steady-state potential, decreases the drift of the potential, and increases the service life of the sensors. The sensors are used to determine antibiotics in the oral fluid and to quantify the main substance (Cefuroxime Axetil) in the Zinnat preparation.
作者简介
E. Kulapina
Chernyshevsky Saratov State University
编辑信件的主要联系方式.
Email: kulapinaeg@mail.ru
俄罗斯联邦, Saratov, 410012
M. Tyutlikova
Chernyshevsky Saratov State University
Email: kulapinaeg@mail.ru
俄罗斯联邦, Saratov, 410012
O. Kulapina
Razumovsky State Medical University
Email: kulapinaeg@mail.ru
俄罗斯联邦, Saratov, 410012
A. Dubasova
Chernyshevsky Saratov State University
Email: kulapinaeg@mail.ru
俄罗斯联邦, Saratov, 410012
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