Solid-Contact Potentiometric Sensors for the Determination of Some Cephalosporin Antibiotics in Pharmaceuticals and Oral Fluid

Abstract

We developed unmodified and polyaniline-modified solid-contact potentiometric sensors based on organic ion exchangers—tetradecylammonium associates and complex compounds of silver(I) with Cefazolin (Cefotaxime, Cefuroxime). The sensors offer a wide analytical range of cephalosporin antibiotics of 1 × 10^–4 (5 × 10^–5) to 0.1 M; the limits of detection for antibiotics are n × 10^–5 M. The introduction of polyaniline shortens the time for reaching the steady-state potential, decreases the drift of the potential, and increases the service life of the sensors. The sensors are used to determine antibiotics in the oral fluid and to quantify the main substance (Cefuroxime Axetil) in the Zinnat preparation.