Comparison of separation performance of polysaccaride-based chiral stationary phases in enantioseparation of 1-(4-chlorobenzhydryl)piperazine benzamide derivatives by HPLC
- 作者: Gurdal E.1, Yarim M.1
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隶属关系:
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy
- 期: 卷 72, 编号 2 (2017)
- 页面: 213-216
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182310
- DOI: https://doi.org/10.1134/S1061934817020046
- ID: 182310
如何引用文章
详细
Analytical high-performance liquid chromatographic enantioseparation of 1-(4-chlorobenzhydryl) piperazine benzamide derivatives was accomplished on different chiral stationary phases. The enantiomers of the compounds were resolved by normal-phase chromatography on silica-based amylose tris(3,5-dimethylphenylcarbamate) (Chiralpak AD-H), cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-H) and cellulose tris(4-methylbenzoate) (Chiralcel OJ) columns with mobile phases consisting of mixtures of n-hexane and ethanol in different proportions (90: 10, 80: 20). The mobile phase and the chiral stationary phase were varied to achieve the best resolution. The effect of the concentration of ethanol in the mobile phase was studied. The resolution obtained on the three columns was significant.
作者简介
Enise Gurdal
Department of Pharmaceutical Chemistry, Faculty of Pharmacy
编辑信件的主要联系方式.
Email: egurdal@yeditepe.edu.tr
土耳其, Kayisdagi, Istanbul, 34755
Mine Yarim
Department of Pharmaceutical Chemistry, Faculty of Pharmacy
Email: egurdal@yeditepe.edu.tr
土耳其, Kayisdagi, Istanbul, 34755
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