A flow-injection amperometric method for determining antiviral guanine derivatives
- 作者: Shpigun L.1, Andryukhina E.1, Kamilova P.1
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隶属关系:
- Kurnakov Institute of General and Inorganic Chemistry
- 期: 卷 71, 编号 6 (2016)
- 页面: 590-597
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/181781
- DOI: https://doi.org/10.1134/S1061934816060150
- ID: 181781
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详细
A flow-injection method is proposed for determining antiviral guanine derivatives, acyclovir, valacyclovir, ganciclovir, and famciclovir, based on their amperometric detection on a carbositall electrode with a preactivated surface. The method is characterized by a wide analytical range, relatively low detection limits (0.6–1.2 μg/mL), and high performance (75 h–1). The results of examination of the accuracy and reproducibility of the analysis of solutions of different pharmaceutical forms containing the test substances are presented. The potentials of the developed flow-injection method in the implementation of the “Dissolution” test in an automated mode are demonstrated.
作者简介
L. Shpigun
Kurnakov Institute of General and Inorganic Chemistry
编辑信件的主要联系方式.
Email: shpigun@igic.ras.ru
俄罗斯联邦, Leninskii pr. 31, Moscow, 119991
E. Andryukhina
Kurnakov Institute of General and Inorganic Chemistry
Email: shpigun@igic.ras.ru
俄罗斯联邦, Leninskii pr. 31, Moscow, 119991
P. Kamilova
Kurnakov Institute of General and Inorganic Chemistry
Email: shpigun@igic.ras.ru
俄罗斯联邦, Leninskii pr. 31, Moscow, 119991
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