A flow-injection amperometric method for determining antiviral guanine derivatives
- Authors: Shpigun L.K.1, Andryukhina E.Y.1, Kamilova P.M.1
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Affiliations:
- Kurnakov Institute of General and Inorganic Chemistry
- Issue: Vol 71, No 6 (2016)
- Pages: 590-597
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/181781
- DOI: https://doi.org/10.1134/S1061934816060150
- ID: 181781
Cite item
Abstract
A flow-injection method is proposed for determining antiviral guanine derivatives, acyclovir, valacyclovir, ganciclovir, and famciclovir, based on their amperometric detection on a carbositall electrode with a preactivated surface. The method is characterized by a wide analytical range, relatively low detection limits (0.6–1.2 μg/mL), and high performance (75 h–1). The results of examination of the accuracy and reproducibility of the analysis of solutions of different pharmaceutical forms containing the test substances are presented. The potentials of the developed flow-injection method in the implementation of the “Dissolution” test in an automated mode are demonstrated.
About the authors
L. K. Shpigun
Kurnakov Institute of General and Inorganic Chemistry
Author for correspondence.
Email: shpigun@igic.ras.ru
Russian Federation, Leninskii pr. 31, Moscow, 119991
E. Yu. Andryukhina
Kurnakov Institute of General and Inorganic Chemistry
Email: shpigun@igic.ras.ru
Russian Federation, Leninskii pr. 31, Moscow, 119991
P. M. Kamilova
Kurnakov Institute of General and Inorganic Chemistry
Email: shpigun@igic.ras.ru
Russian Federation, Leninskii pr. 31, Moscow, 119991