A flow-injection amperometric method for determining antiviral guanine derivatives
- Авторы: Shpigun L.1, Andryukhina E.1, Kamilova P.1
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Учреждения:
- Kurnakov Institute of General and Inorganic Chemistry
- Выпуск: Том 71, № 6 (2016)
- Страницы: 590-597
- Раздел: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/181781
- DOI: https://doi.org/10.1134/S1061934816060150
- ID: 181781
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Аннотация
A flow-injection method is proposed for determining antiviral guanine derivatives, acyclovir, valacyclovir, ganciclovir, and famciclovir, based on their amperometric detection on a carbositall electrode with a preactivated surface. The method is characterized by a wide analytical range, relatively low detection limits (0.6–1.2 μg/mL), and high performance (75 h–1). The results of examination of the accuracy and reproducibility of the analysis of solutions of different pharmaceutical forms containing the test substances are presented. The potentials of the developed flow-injection method in the implementation of the “Dissolution” test in an automated mode are demonstrated.
Об авторах
L. Shpigun
Kurnakov Institute of General and Inorganic Chemistry
Автор, ответственный за переписку.
Email: shpigun@igic.ras.ru
Россия, Leninskii pr. 31, Moscow, 119991
E. Andryukhina
Kurnakov Institute of General and Inorganic Chemistry
Email: shpigun@igic.ras.ru
Россия, Leninskii pr. 31, Moscow, 119991
P. Kamilova
Kurnakov Institute of General and Inorganic Chemistry
Email: shpigun@igic.ras.ru
Россия, Leninskii pr. 31, Moscow, 119991