Matrix Interference in the Determination of Elements in Biological Samples by Inductively Coupled Plasma–Mass Spectrometry and Methods for Its Elimination
- Авторлар: Seregina I.1, Osipov K.2, Bol’shov M.1,3, Filatova D.1, Lanskaya S.1
-
Мекемелер:
- Department of Chemistry, Moscow State University
- Moscow Institute of Physics and Technology
- Institute of Spectroscopy, Russian Academy of Sciences
- Шығарылым: Том 74, № 2 (2019)
- Беттер: 182-191
- Бөлім: Reviews
- URL: https://journals.rcsi.science/1061-9348/article/view/183155
- DOI: https://doi.org/10.1134/S1061934819020114
- ID: 183155
Дәйексөз келтіру
Аннотация
The problems of detecting and accounting for spectral and nonspectral interferences arising in the determination of a wide range of elements in biological and pharmaceutical samples by inductively coupled plasma–mass spectrometry are discussed. We studied the features of the effect of matrix components on the accuracy of the results of analysis of biological fluids and pharmaceuticals using a quadrupole mass spectrometer. The processes that have the most significant effect on the suppression of an analytical signal measured by an Agilent 7500c quadrupole mass spectrometer are revealed. The main operational parameters responsible for minimizing the investigated nonspectral interference are determined. Various versions of the internal standard method are studied, which offer a decrease in the effect of the sample composition on the determination results. A direct relationship is found between various modes of operation of the instrument and the criteria for selecting an internal standard. Combined approaches to the complete elimination of nonspectral interference using external calibration are proposed. A method is proposed for decreasing the acidity of the test solution by adsorption separation of the analyte elements and acid.
Авторлар туралы
I. Seregina
Department of Chemistry, Moscow State University
Хат алмасуға жауапты Автор.
Email: sereginairinaf@mail.ru
Ресей, Moscow, 119991
K. Osipov
Moscow Institute of Physics and Technology
Email: sereginairinaf@mail.ru
Ресей, Dolgoprudnyi, Moscow oblast, 141701
M. Bol’shov
Department of Chemistry, Moscow State University; Institute of Spectroscopy, Russian Academy of Sciences
Email: sereginairinaf@mail.ru
Ресей, Moscow, 119991; Troitsk, Moscow oblast, 108840
D. Filatova
Department of Chemistry, Moscow State University
Email: sereginairinaf@mail.ru
Ресей, Moscow, 119991
S. Lanskaya
Department of Chemistry, Moscow State University
Email: sereginairinaf@mail.ru
Ресей, Moscow, 119991