Email this article An Experimental Design Approach for Optimization of Spectrophotometric Estimation of Mirabegron in Bulk and Pharmaceutical Formulations
- Authors: Roopa Kothathi Papanna 1,2, Gowda J.B.3, Nagaraja P.4
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Affiliations:
- R & D Centre, Bharathiar University, Coimbatore
- Department of Chemistry, Sapthagiri College of Engineering
- Department of Chemistry, B.N.M. Institute of Technology
- Department of Studies in Chemistry, University of Mysore
- Issue: Vol 73, No 9 (2018)
- Pages: 884-893
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182823
- DOI: https://doi.org/10.1134/S1061934818090095
- ID: 182823
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Abstract
Three simple, low-cost, sensitive and diversely applicable UV-Vis spectrophotometric methods have been developed for the estimation of drug Mirabegron. Method A is based on the reaction of Mirabegron with ninhydrin in the presence of sodium molybdate at pH 5.5. Method B is based on the reaction of the drug with 1,2-napthaquinone-4-sulphonate and cetyltrimethyl ammonium bromide in an alkaline medium. Method C is based on a redox reaction of the drug with Folin–Ciocalteu reagent in sodium carbonate medium. Beer’s law was obeyed in the concentration ranges of 2.5–22.5, 5–35, and 5–70 μg/mL for methods A, B, and C. The proposed methods can be applied to drug formulation and recommended for the routine analysis in quality control laboratories.
About the authors
Roopa Kothathi Papanna
R & D Centre, Bharathiar University, Coimbatore; Department of Chemistry, Sapthagiri College of Engineering
Author for correspondence.
Email: roopakp@sapthagiri.edu.in
India,
Bangalore
Jayanna Bidarur Krishne Gowda
Department of Chemistry, B.N.M. Institute of Technology
Email: roopakp@sapthagiri.edu.in
India, Bangalore
Padmarajaiah Nagaraja
Department of Studies in Chemistry, University of Mysore
Email: roopakp@sapthagiri.edu.in
India, Manasagangothri Mysore
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