Enviar artigo por via de e-mail An Experimental Design Approach for Optimization of Spectrophotometric Estimation of Mirabegron in Bulk and Pharmaceutical Formulations
- Autores: Roopa Kothathi Papanna 1,2, Gowda J.3, Nagaraja P.4
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Afiliações:
- R & D Centre, Bharathiar University, Coimbatore
- Department of Chemistry, Sapthagiri College of Engineering
- Department of Chemistry, B.N.M. Institute of Technology
- Department of Studies in Chemistry, University of Mysore
- Edição: Volume 73, Nº 9 (2018)
- Páginas: 884-893
- Seção: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182823
- DOI: https://doi.org/10.1134/S1061934818090095
- ID: 182823
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Resumo
Three simple, low-cost, sensitive and diversely applicable UV-Vis spectrophotometric methods have been developed for the estimation of drug Mirabegron. Method A is based on the reaction of Mirabegron with ninhydrin in the presence of sodium molybdate at pH 5.5. Method B is based on the reaction of the drug with 1,2-napthaquinone-4-sulphonate and cetyltrimethyl ammonium bromide in an alkaline medium. Method C is based on a redox reaction of the drug with Folin–Ciocalteu reagent in sodium carbonate medium. Beer’s law was obeyed in the concentration ranges of 2.5–22.5, 5–35, and 5–70 μg/mL for methods A, B, and C. The proposed methods can be applied to drug formulation and recommended for the routine analysis in quality control laboratories.
Sobre autores
Roopa Kothathi Papanna
R & D Centre, Bharathiar University, Coimbatore; Department of Chemistry, Sapthagiri College of Engineering
Autor responsável pela correspondência
Email: roopakp@sapthagiri.edu.in
Índia,
Bangalore
Jayanna Gowda
Department of Chemistry, B.N.M. Institute of Technology
Email: roopakp@sapthagiri.edu.in
Índia, Bangalore
Padmarajaiah Nagaraja
Department of Studies in Chemistry, University of Mysore
Email: roopakp@sapthagiri.edu.in
Índia, Manasagangothri Mysore
