Development of a toolkit for early precision immunochromatographic diagnosis
- Authors: Krylsky D.V.1, Gushchin A.P.1, Gushchin S.A.1, Dezhurov S.V.1, Morenkov O.S.2, Gladyshev P.P.3, Vasiliev A.A.4
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Affiliations:
- Research Institute of Applied Acoustics
- Institute of Cell Biophysics
- Department of Natural Sciences and Engineering
- National Research Centre “Kurchatov Institute,”
- Issue: Vol 71, No 10 (2016)
- Pages: 1063-1068
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182130
- DOI: https://doi.org/10.1134/S1061934816100063
- ID: 182130
Cite item
Abstract
A device is developed for automated immunochromatographic assay, designed for one-time tests at the place of occurrence of a disease. The device comprises a turntable platform for up to five strips placed simultaneously, a unit for sample collection and microdosing to a test strip, a detection unit, and a microprocessor control system. A manual, semiautomatic, or automatic operation mode may be selected. Colloidal quantum dots with a luminescence peak from the visible to near-infrared spectral region (600–800 nm) are used as fluorescent labels. A UV-LED or a laser at 365–480 nm can be used as an excitation system; the detection device is a spectrometer with an operation range of 500–800 nm, based on a CCD series of TCD1304DG sensors (Toshiba). RFID tags of samples can re read and the analysis results can be sent to an external computer. The device is made in a plastic case for carrying.
About the authors
D. V. Krylsky
Research Institute of Applied Acoustics
Author for correspondence.
Email: krdvmail@mail.ru
Russian Federation, ul. 9 Maya 7a, Dubna, Moscow oblast, 141980
A. P. Gushchin
Research Institute of Applied Acoustics
Email: krdvmail@mail.ru
Russian Federation, ul. 9 Maya 7a, Dubna, Moscow oblast, 141980
S. A. Gushchin
Research Institute of Applied Acoustics
Email: krdvmail@mail.ru
Russian Federation, ul. 9 Maya 7a, Dubna, Moscow oblast, 141980
S. V. Dezhurov
Research Institute of Applied Acoustics
Email: krdvmail@mail.ru
Russian Federation, ul. 9 Maya 7a, Dubna, Moscow oblast, 141980
O. S. Morenkov
Institute of Cell Biophysics
Email: krdvmail@mail.ru
Russian Federation, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290
P. P. Gladyshev
Department of Natural Sciences and Engineering
Email: krdvmail@mail.ru
Russian Federation, Universitetskaya ul. 19, Dubna, Moscow oblast, 141980
A. A. Vasiliev
National Research Centre “Kurchatov Institute,”
Email: krdvmail@mail.ru
Russian Federation, pl. Akademika Kurchatova 1, Moscow, 123098