Development of a toolkit for early precision immunochromatographic diagnosis

Abstract

A device is developed for automated immunochromatographic assay, designed for one-time tests at the place of occurrence of a disease. The device comprises a turntable platform for up to five strips placed simultaneously, a unit for sample collection and microdosing to a test strip, a detection unit, and a microprocessor control system. A manual, semiautomatic, or automatic operation mode may be selected. Colloidal quantum dots with a luminescence peak from the visible to near-infrared spectral region (600–800 nm) are used as fluorescent labels. A UV-LED or a laser at 365–480 nm can be used as an excitation system; the detection device is a spectrometer with an operation range of 500–800 nm, based on a CCD series of TCD1304DG sensors (Toshiba). RFID tags of samples can re read and the analysis results can be sent to an external computer. The device is made in a plastic case for carrying.