Determination of Nitrofuran Metabolites in Muscular Tissue by High-Performance Liquid Chromatography with Mass Spectrometric Detection
- Authors: Kulikovskii A.V.1,2, Gorlov I.F.1, Slozhenkina M.I.1, Vostrikova N.L.2, Ivankin A.N.2, Kuznetsova O.A.2
-
Affiliations:
- Volga Research Institute of Production and Processing of Meat and Dairy Products
- V.M. Gorbatov Federal Research Center for Food Systems, Russian Academy of Sciences
- Issue: Vol 74, No 9 (2019)
- Pages: 906-912
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/183305
- DOI: https://doi.org/10.1134/S106193481907013X
- ID: 183305
Cite item
Abstract
We developed a procedure for determining residual amounts of four nitrofuran metabolites (3‑amino-2-oxazolidinone, 3-amino-5-methylmorpholino-2-oxazolidinone, 1-aminohydantoin hydrochloride, and semicarbazide hydrochloride) in muscle tissue in the form of 2-nitrophenyl derivatives by HPLC with selected reaction monitoring mass spectrometric detection. The effect of the matrix suppression of ionization is shown. The selectivity of extraction is increased by optimizing the sample preparation procedure, and the effect of organic impurities on the result measurements is minimized. The lower limit of the analytical range is 10 μg/kg for semicarbazide hydrochloride and 1 μg/kg for the remaining nitrofuran metabolites.
About the authors
A. V. Kulikovskii
Volga Research Institute of Production and Processing of Meat and Dairy Products; V.M. Gorbatov Federal Research Center for Food Systems, Russian Academy of Sciences
Author for correspondence.
Email: a.kulikovskii@fncps.ru
Russian Federation, Volgograd, 400131; Moscow, 109316
I. F. Gorlov
Volga Research Institute of Production and Processing of Meat and Dairy Products
Email: a.kulikovskii@fncps.ru
Russian Federation, Volgograd, 400131
M. I. Slozhenkina
Volga Research Institute of Production and Processing of Meat and Dairy Products
Email: a.kulikovskii@fncps.ru
Russian Federation, Volgograd, 400131
N. L. Vostrikova
V.M. Gorbatov Federal Research Center for Food Systems, Russian Academy of Sciences
Email: a.kulikovskii@fncps.ru
Russian Federation, Moscow, 109316
A. N. Ivankin
V.M. Gorbatov Federal Research Center for Food Systems, Russian Academy of Sciences
Email: a.kulikovskii@fncps.ru
Russian Federation, Moscow, 109316
O. A. Kuznetsova
V.M. Gorbatov Federal Research Center for Food Systems, Russian Academy of Sciences
Email: a.kulikovskii@fncps.ru
Russian Federation, Moscow, 109316
![](/img/style/loading.gif)