Determination of Methylphosphonic Acid in Human Blood Plasma by High-Performance Liquid Chromatography–Tandem Mass Spectrometry
- Authors: Baygildiev T.M.1, Rodin I.A.1, Stavrianidi A.N.1, Braun A.V.2, Shpigun O.A.2, Rybalchenko I.V.2
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Affiliations:
- Department of Chemistry
- Kostroma State Technological University
- Issue: Vol 72, No 13 (2017)
- Pages: 1307-1311
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182714
- DOI: https://doi.org/10.1134/S1061934817130020
- ID: 182714
Cite item
Abstract
Using high-performance liquid chromatography combined with tandem mass spectrometric detection, an approach has been developed for the determination of the most stable nerve agent biomarker, methylphosphonic acid, in human blood plasma. The proposed method is based on the derivatization of methylphosphonic acid with p-bromophenacyl bromide. The optimization of conditions for human plasma sample preparation, mass spectrometric detection conditions, and gradient elution program has been performed. The proposed approach has demonstrated satisfactory reproducibility and selectivity of the determination; the limit of detection for methylphosphonic acid in human plasma was 3 ng mL–1.
About the authors
T. M. Baygildiev
Department of Chemistry
Author for correspondence.
Email: timurbaychem@gmail.com
Russian Federation, Moscow, 119991
I. A. Rodin
Department of Chemistry
Email: timurbaychem@gmail.com
Russian Federation, Moscow, 119991
A. N. Stavrianidi
Department of Chemistry
Email: timurbaychem@gmail.com
Russian Federation, Moscow, 119991
A. V. Braun
Kostroma State Technological University
Email: timurbaychem@gmail.com
Russian Federation, Kostroma, 156005
O. A. Shpigun
Kostroma State Technological University
Email: timurbaychem@gmail.com
Russian Federation, Kostroma, 156005
I. V. Rybalchenko
Kostroma State Technological University
Email: timurbaychem@gmail.com
Russian Federation, Kostroma, 156005