Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry
- Authors: Topolyan A.P.1, Formanovsky A.A.1, Mikhura I.V.1, Ustinov A.V.1, Korshun V.A.1,2, Ivanova O.M.1, Belyaeva M.A.1, Slyundina M.S.2,3, Strizhevskaya D.A.1, Borisov R.S.3,4
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
- Gause Institute of New Antibiotics
- Topchiev Institute of Petrochemical Synthesis
- Peoples Friendship University of Russia
- Issue: Vol 71, No 14 (2016)
- Pages: 1326-1331
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182238
- DOI: https://doi.org/10.1134/S106193481614015X
- ID: 182238
Cite item
Abstract
A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents.
Keywords
About the authors
A. P. Topolyan
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 117997
A. A. Formanovsky
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 117997
I. V. Mikhura
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 117997
A. V. Ustinov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 117997
V. A. Korshun
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry; Gause Institute of New Antibiotics
Author for correspondence.
Email: v-korshun@yandex.ru
Russian Federation, Moscow, 117997; Moscow, 119021
O. M. Ivanova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 117997
M. A. Belyaeva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 117997
M. S. Slyundina
Gause Institute of New Antibiotics; Topchiev Institute of Petrochemical Synthesis
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 119021; Moscow, 119991
D. A. Strizhevskaya
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 117997
R. S. Borisov
Topchiev Institute of Petrochemical Synthesis; Peoples Friendship University of Russia
Author for correspondence.
Email: borisov@ips.ac.ru
Russian Federation, Moscow, 119991; Moscow, 117198
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