Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry

A. P. Topolyan; A. A. Formanovsky; I. V. Mikhura; A. V. Ustinov; V. A. Korshun; O. M. Ivanova; M. A. Belyaeva; M. S. Slyundina; D. A. Strizhevskaya; R. S. Borisov

doi:10.1134/S106193481614015X

Tris(2,6-dimethoxyphenyl)methyl carbenium ion as a charge derivatization agent for the analysis of primary amines by MALDI mass spectrometry

Авторы: Topolyan A.¹, Formanovsky A.¹, Mikhura I.¹, Ustinov A.¹, Korshun V.¹^,2, Ivanova O.¹, Belyaeva M.¹, Slyundina M.²^,3, Strizhevskaya D.¹, Borisov R.³^,4
Учреждения:
1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
2. Gause Institute of New Antibiotics
3. Topchiev Institute of Petrochemical Synthesis
4. Peoples Friendship University of Russia
Выпуск: Том 71, № 14 (2016)
Страницы: 1326-1331
Раздел: Articles
URL: https://journals.rcsi.science/1061-9348/article/view/182238
DOI: https://doi.org/10.1134/S106193481614015X
ID: 182238

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Аннотация

A novel derivatization method for the analysis of primary amines by MALDI mass spectrometry is proposed. Tris(2,6-dimethoxyphenyl) methyl carbenium cation reacts smoothly with primary amines, forming permanently charged adducts with the mass increment +359 Da and absorbance in the UV region. The approach was tested on a number of amines, including biologically active compounds and therapeutic agents.