Email this article Electrophoretic separation of some nucleosides for the diagnosis of mastopathy and fibroadenoma
- Authors: Jiang M.1, Prokhorova A.F.2, Rozhmanova N.B.2, Shpigun O.A.2
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Affiliations:
- Hutchison MediPharma, Zhangjiang Hi-Tech Park
- Department of Chemistry
- Issue: Vol 71, No 12 (2016)
- Pages: 1198-1203
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182198
- DOI: https://doi.org/10.1134/S1061934816120091
- ID: 182198
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Abstract
Mixtures of 13 normal and modified nucleosides in a 70 mM phosphate buffer solution (pH 6.7) supplemented with 100 mM of sodium dodecyl sulfate were separated by micellar electrokinetic chromatography in 25 min. Electrophoretic profiles of urine are obtained; it is demonstrated that 1-methylinosine and 1-methylguanosine nucleosides can be used as markers of precancerous states (mastopathy) and benign tumors (fibroadenoma).
About the authors
Mingsheng Jiang
Hutchison MediPharma, Zhangjiang Hi-Tech Park
Email: alexapro@gmail.com
China, Shanghai, 201203
A. F. Prokhorova
Department of Chemistry
Author for correspondence.
Email: alexapro@gmail.com
Russian Federation, Moscow, 119991
N. B. Rozhmanova
Department of Chemistry
Email: alexapro@gmail.com
Russian Federation, Moscow, 119991
O. A. Shpigun
Department of Chemistry
Email: alexapro@gmail.com
Russian Federation, Moscow, 119991
