Generation of urinary steroid profiles in patients with adrenal incidentaloma using gas chromatography–mass spectrometry

L. I. Velikanova; E. G. Strel’nikova; E. V. Obedkova; N. S. Krivokhizhina; Z. R. Shafigullina; K. Grigoryan; V. G. Povarov; A. L. Moskvin

doi:10.1134/S1061934816070169

Generation of urinary steroid profiles in patients with adrenal incidentaloma using gas chromatography–mass spectrometry

Авторы: Velikanova L.I.¹, Strel’nikova E.G.¹, Obedkova E.V.¹, Krivokhizhina N.S.¹, Shafigullina Z.R.¹, Grigoryan K.¹, Povarov V.G.², Moskvin A.L.²
Учреждения:
1. Northwestern State Medical University
2. St. Petersburg State University
Выпуск: Том 71, № 7 (2016)
Страницы: 748-754
Раздел: Articles
URL: https://journals.rcsi.science/1061-9348/article/view/181930
DOI: https://doi.org/10.1134/S1061934816070169
ID: 181930

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Аннотация

A method is developed for the determination of steroid hormones in urine using gas chromatography with mass-spectrometric detection. Sample preparation procedure and the conditions of chromatographic analysis were optimized, and characteristic urinary steroid profiles of patients with adrenocortical cancer were obtained. Criteria for the evaluation of the deficiency of 21-hydroxylase and 11β-hydroxylase in patients with adrenal incidentaloma are proposed.