High-performance liquid chromatography–time-of-flight mass spectrometry in the identification and determination of 111 pesticides in food, feed, water, and soil

Abstract

A method has been proposed for the simultaneous identification and determination of 111 pesticides from various classes in food by high-performance liquid chromatography–high-resolution time-offlight mass spectrometry combined with simple and fast sample preparation. Possibility of the identification and determination of pesticides in drinking, natural, and ground waters without sample preparation has been demonstrated. A scheme of the identification and determination of the detected analytes using the standard addition method has been suggested. The limit of detection is 0.05 (0.1) µg/(L)kg. The relative standard deviation of the results of analysis does not exceed 0.1. The time of identification is 30–40 min and time of determination is 1–2 h.