Mutational landscape of prostate tumors revealed by whole-exome sequencing
- Авторы: Gilyazova I.1,2, Yankina M.2, Kunsbaeva G.1, Klimentova E.2, Izmaylov A.3, Pavlov V.3, Khusnutdinova E.1,2
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Учреждения:
- Department of Genetics and Medicine
- Institute of Biochemistry and Genetics, Ufa Research Center
- Department of Urology
- Выпуск: Том 52, № 9 (2016)
- Страницы: 999-1003
- Раздел: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/187902
- DOI: https://doi.org/10.1134/S1022795416090052
- ID: 187902
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Аннотация
The results of the whole-exome DNA sequencing of eight prostate adenocarcinoma patients are presented. DNA was isolated from the peripheral blood as well as healthy and tumor prostate tissue from each patient. Bioinformatics analysis was conducted and the most significant mutations in prostate cancer patients were revealed. The obtained data could be important for understanding of the molecular mechanisms of prostate cancer pathogenesis and facilitate development of new approaches for treatment of the disease.
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Об авторах
I. Gilyazova
Department of Genetics and Medicine; Institute of Biochemistry and Genetics, Ufa Research Center
Автор, ответственный за переписку.
Email: gilyasova_irina@mail.ru
Россия, Ufa, 450074; Ufa, 450054
M. Yankina
Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Россия, Ufa, 450054
G. Kunsbaeva
Department of Genetics and Medicine
Email: gilyasova_irina@mail.ru
Россия, Ufa, 450074
E. Klimentova
Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Россия, Ufa, 450054
A. Izmaylov
Department of Urology
Email: gilyasova_irina@mail.ru
Россия, Ufa, 450000
V. Pavlov
Department of Urology
Email: gilyasova_irina@mail.ru
Россия, Ufa, 450000
E. Khusnutdinova
Department of Genetics and Medicine; Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Россия, Ufa, 450074; Ufa, 450054