Mutational landscape of prostate tumors revealed by whole-exome sequencing
- Autores: Gilyazova I.1,2, Yankina M.2, Kunsbaeva G.1, Klimentova E.2, Izmaylov A.3, Pavlov V.3, Khusnutdinova E.1,2
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Afiliações:
- Department of Genetics and Medicine
- Institute of Biochemistry and Genetics, Ufa Research Center
- Department of Urology
- Edição: Volume 52, Nº 9 (2016)
- Páginas: 999-1003
- Seção: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/187902
- DOI: https://doi.org/10.1134/S1022795416090052
- ID: 187902
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Resumo
The results of the whole-exome DNA sequencing of eight prostate adenocarcinoma patients are presented. DNA was isolated from the peripheral blood as well as healthy and tumor prostate tissue from each patient. Bioinformatics analysis was conducted and the most significant mutations in prostate cancer patients were revealed. The obtained data could be important for understanding of the molecular mechanisms of prostate cancer pathogenesis and facilitate development of new approaches for treatment of the disease.
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Sobre autores
I. Gilyazova
Department of Genetics and Medicine; Institute of Biochemistry and Genetics, Ufa Research Center
Autor responsável pela correspondência
Email: gilyasova_irina@mail.ru
Rússia, Ufa, 450074; Ufa, 450054
M. Yankina
Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Rússia, Ufa, 450054
G. Kunsbaeva
Department of Genetics and Medicine
Email: gilyasova_irina@mail.ru
Rússia, Ufa, 450074
E. Klimentova
Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Rússia, Ufa, 450054
A. Izmaylov
Department of Urology
Email: gilyasova_irina@mail.ru
Rússia, Ufa, 450000
V. Pavlov
Department of Urology
Email: gilyasova_irina@mail.ru
Rússia, Ufa, 450000
E. Khusnutdinova
Department of Genetics and Medicine; Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Rússia, Ufa, 450074; Ufa, 450054