Mutational landscape of prostate tumors revealed by whole-exome sequencing
- Authors: Gilyazova I.R.1,2, Yankina M.A.2, Kunsbaeva G.B.1, Klimentova E.A.2, Izmaylov A.A.3, Pavlov V.N.3, Khusnutdinova E.K.1,2
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Affiliations:
- Department of Genetics and Medicine
- Institute of Biochemistry and Genetics, Ufa Research Center
- Department of Urology
- Issue: Vol 52, No 9 (2016)
- Pages: 999-1003
- Section: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/187902
- DOI: https://doi.org/10.1134/S1022795416090052
- ID: 187902
Cite item
Abstract
The results of the whole-exome DNA sequencing of eight prostate adenocarcinoma patients are presented. DNA was isolated from the peripheral blood as well as healthy and tumor prostate tissue from each patient. Bioinformatics analysis was conducted and the most significant mutations in prostate cancer patients were revealed. The obtained data could be important for understanding of the molecular mechanisms of prostate cancer pathogenesis and facilitate development of new approaches for treatment of the disease.
About the authors
I. R. Gilyazova
Department of Genetics and Medicine; Institute of Biochemistry and Genetics, Ufa Research Center
Author for correspondence.
Email: gilyasova_irina@mail.ru
Russian Federation, Ufa, 450074; Ufa, 450054
M. A. Yankina
Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Russian Federation, Ufa, 450054
G. B. Kunsbaeva
Department of Genetics and Medicine
Email: gilyasova_irina@mail.ru
Russian Federation, Ufa, 450074
E. A. Klimentova
Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Russian Federation, Ufa, 450054
A. A. Izmaylov
Department of Urology
Email: gilyasova_irina@mail.ru
Russian Federation, Ufa, 450000
V. N. Pavlov
Department of Urology
Email: gilyasova_irina@mail.ru
Russian Federation, Ufa, 450000
E. K. Khusnutdinova
Department of Genetics and Medicine; Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Russian Federation, Ufa, 450074; Ufa, 450054