Mutational landscape of prostate tumors revealed by whole-exome sequencing
- Авторлар: Gilyazova I.1,2, Yankina M.2, Kunsbaeva G.1, Klimentova E.2, Izmaylov A.3, Pavlov V.3, Khusnutdinova E.1,2
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Мекемелер:
- Department of Genetics and Medicine
- Institute of Biochemistry and Genetics, Ufa Research Center
- Department of Urology
- Шығарылым: Том 52, № 9 (2016)
- Беттер: 999-1003
- Бөлім: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/187902
- DOI: https://doi.org/10.1134/S1022795416090052
- ID: 187902
Дәйексөз келтіру
Аннотация
The results of the whole-exome DNA sequencing of eight prostate adenocarcinoma patients are presented. DNA was isolated from the peripheral blood as well as healthy and tumor prostate tissue from each patient. Bioinformatics analysis was conducted and the most significant mutations in prostate cancer patients were revealed. The obtained data could be important for understanding of the molecular mechanisms of prostate cancer pathogenesis and facilitate development of new approaches for treatment of the disease.
Негізгі сөздер
Авторлар туралы
I. Gilyazova
Department of Genetics and Medicine; Institute of Biochemistry and Genetics, Ufa Research Center
Хат алмасуға жауапты Автор.
Email: gilyasova_irina@mail.ru
Ресей, Ufa, 450074; Ufa, 450054
M. Yankina
Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Ресей, Ufa, 450054
G. Kunsbaeva
Department of Genetics and Medicine
Email: gilyasova_irina@mail.ru
Ресей, Ufa, 450074
E. Klimentova
Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Ресей, Ufa, 450054
A. Izmaylov
Department of Urology
Email: gilyasova_irina@mail.ru
Ресей, Ufa, 450000
V. Pavlov
Department of Urology
Email: gilyasova_irina@mail.ru
Ресей, Ufa, 450000
E. Khusnutdinova
Department of Genetics and Medicine; Institute of Biochemistry and Genetics, Ufa Research Center
Email: gilyasova_irina@mail.ru
Ресей, Ufa, 450074; Ufa, 450054