Insertion Mutations of the shaggy Gene, Encoding Protein Kinase GSK3, Extend Drosophila melanogaster Lifespan
- Авторлар: Trostnikov M.1,2, Veselkina E.1, Krementsova A.1,3, Roshina N.1,2, Pasyukova E.1
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Мекемелер:
- Institute of Molecular Genetics, Russian Academy of Sciences
- Vavilov Institute of General Genetics, Russian Academy of Sciences
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Шығарылым: Том 55, № 9 (2019)
- Беттер: 1165-1170
- Бөлім: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/189575
- DOI: https://doi.org/10.1134/S1022795419090163
- ID: 189575
Дәйексөз келтіру
Аннотация
The shaggy gene of Drosophila melanogaster encodes highly conserved serine-threonine protein kinase GSK3 (Glycogen Syntase Kinase 3), which plays an important role in different signaling pathways and metabolic processes. This study is the first to demonstrate that shaggy mutations affect lifespan, with an increase in longevity associated with a decrease in synapse activity. The results from this study on changes in shaggy expression in mutants suggest that the observed phenotypic changes are based on an alternation in the expression of minor shaggy transcripts induced by mutational changes in their regulatory region.
Негізгі сөздер
Авторлар туралы
M. Trostnikov
Institute of Molecular Genetics, Russian Academy of Sciences; Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
Ресей, Moscow, 123182; Moscow, 119991
E. Veselkina
Institute of Molecular Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
Ресей, Moscow, 123182
A. Krementsova
Institute of Molecular Genetics, Russian Academy of Sciences; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: egpas@rambler.ru
Ресей, Moscow, 123182; Moscow, 119334
N. Roshina
Institute of Molecular Genetics, Russian Academy of Sciences; Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
Ресей, Moscow, 123182; Moscow, 119991
E. Pasyukova
Institute of Molecular Genetics, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: egpas@rambler.ru
Ресей, Moscow, 123182