Insertion Mutations of the shaggy Gene, Encoding Protein Kinase GSK3, Extend Drosophila melanogaster Lifespan
- Авторы: Trostnikov M.1,2, Veselkina E.1, Krementsova A.1,3, Roshina N.1,2, Pasyukova E.1
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Учреждения:
- Institute of Molecular Genetics, Russian Academy of Sciences
- Vavilov Institute of General Genetics, Russian Academy of Sciences
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Выпуск: Том 55, № 9 (2019)
- Страницы: 1165-1170
- Раздел: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/189575
- DOI: https://doi.org/10.1134/S1022795419090163
- ID: 189575
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Аннотация
The shaggy gene of Drosophila melanogaster encodes highly conserved serine-threonine protein kinase GSK3 (Glycogen Syntase Kinase 3), which plays an important role in different signaling pathways and metabolic processes. This study is the first to demonstrate that shaggy mutations affect lifespan, with an increase in longevity associated with a decrease in synapse activity. The results from this study on changes in shaggy expression in mutants suggest that the observed phenotypic changes are based on an alternation in the expression of minor shaggy transcripts induced by mutational changes in their regulatory region.
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Об авторах
M. Trostnikov
Institute of Molecular Genetics, Russian Academy of Sciences; Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
Россия, Moscow, 123182; Moscow, 119991
E. Veselkina
Institute of Molecular Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
Россия, Moscow, 123182
A. Krementsova
Institute of Molecular Genetics, Russian Academy of Sciences; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: egpas@rambler.ru
Россия, Moscow, 123182; Moscow, 119334
N. Roshina
Institute of Molecular Genetics, Russian Academy of Sciences; Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
Россия, Moscow, 123182; Moscow, 119991
E. Pasyukova
Institute of Molecular Genetics, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: egpas@rambler.ru
Россия, Moscow, 123182