Insertion Mutations of the shaggy Gene, Encoding Protein Kinase GSK3, Extend Drosophila melanogaster Lifespan
- Authors: Trostnikov M.V.1,2, Veselkina E.R.1, Krementsova A.V.1,3, Roshina N.V.1,2, Pasyukova E.G.1
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Affiliations:
- Institute of Molecular Genetics, Russian Academy of Sciences
- Vavilov Institute of General Genetics, Russian Academy of Sciences
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 55, No 9 (2019)
- Pages: 1165-1170
- Section: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/189575
- DOI: https://doi.org/10.1134/S1022795419090163
- ID: 189575
Cite item
Abstract
The shaggy gene of Drosophila melanogaster encodes highly conserved serine-threonine protein kinase GSK3 (Glycogen Syntase Kinase 3), which plays an important role in different signaling pathways and metabolic processes. This study is the first to demonstrate that shaggy mutations affect lifespan, with an increase in longevity associated with a decrease in synapse activity. The results from this study on changes in shaggy expression in mutants suggest that the observed phenotypic changes are based on an alternation in the expression of minor shaggy transcripts induced by mutational changes in their regulatory region.
About the authors
M. V. Trostnikov
Institute of Molecular Genetics, Russian Academy of Sciences; Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
Russian Federation, Moscow, 123182; Moscow, 119991
E. R. Veselkina
Institute of Molecular Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
Russian Federation, Moscow, 123182
A. V. Krementsova
Institute of Molecular Genetics, Russian Academy of Sciences; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: egpas@rambler.ru
Russian Federation, Moscow, 123182; Moscow, 119334
N. V. Roshina
Institute of Molecular Genetics, Russian Academy of Sciences; Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
Russian Federation, Moscow, 123182; Moscow, 119991
E. G. Pasyukova
Institute of Molecular Genetics, Russian Academy of Sciences
Author for correspondence.
Email: egpas@rambler.ru
Russian Federation, Moscow, 123182