Insertion Mutations of the shaggy Gene, Encoding Protein Kinase GSK3, Extend Drosophila melanogaster Lifespan
- 作者: Trostnikov M.1,2, Veselkina E.1, Krementsova A.1,3, Roshina N.1,2, Pasyukova E.1
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隶属关系:
- Institute of Molecular Genetics, Russian Academy of Sciences
- Vavilov Institute of General Genetics, Russian Academy of Sciences
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- 期: 卷 55, 编号 9 (2019)
- 页面: 1165-1170
- 栏目: Short Communications
- URL: https://journals.rcsi.science/1022-7954/article/view/189575
- DOI: https://doi.org/10.1134/S1022795419090163
- ID: 189575
如何引用文章
详细
The shaggy gene of Drosophila melanogaster encodes highly conserved serine-threonine protein kinase GSK3 (Glycogen Syntase Kinase 3), which plays an important role in different signaling pathways and metabolic processes. This study is the first to demonstrate that shaggy mutations affect lifespan, with an increase in longevity associated with a decrease in synapse activity. The results from this study on changes in shaggy expression in mutants suggest that the observed phenotypic changes are based on an alternation in the expression of minor shaggy transcripts induced by mutational changes in their regulatory region.
作者简介
M. Trostnikov
Institute of Molecular Genetics, Russian Academy of Sciences; Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
俄罗斯联邦, Moscow, 123182; Moscow, 119991
E. Veselkina
Institute of Molecular Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
俄罗斯联邦, Moscow, 123182
A. Krementsova
Institute of Molecular Genetics, Russian Academy of Sciences; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: egpas@rambler.ru
俄罗斯联邦, Moscow, 123182; Moscow, 119334
N. Roshina
Institute of Molecular Genetics, Russian Academy of Sciences; Vavilov Institute of General Genetics, Russian Academy of Sciences
Email: egpas@rambler.ru
俄罗斯联邦, Moscow, 123182; Moscow, 119991
E. Pasyukova
Institute of Molecular Genetics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: egpas@rambler.ru
俄罗斯联邦, Moscow, 123182