Experimental Models of Synaptopathies Based on Zebrafish

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Abstract

Synaptopathies include a heterogeneous group of severely debilitating neurological diseases characterized by structural and functional deficits of neuronal synapses. Common synaptopathies include epilepsy, schizophrenia, prion diseases, autism spectrum disorders, various autoimmune diseases and cochlear synaptopathies. Their pathogenesis is caused by both genetic and environmental factors. However, the relationship between the cause and clinical manifestations of each particular synaptopathy, and their therapy, remain poorly understood. Here, we discuss animal models of synaptopathies, with a specific emphasis on zebrafish (Danio rerio), as well as outline several lines of future research in this field. Overall, zebrafish emerge as a promising organism to mimic a wide range of synaptopahies, paralleling and complementing their existing models in rodents.

About the authors

A. S. Lebedev

World-class Scientific Research Center “Center of Personalized Medicine”,
Almazov National Medical Research Center Ministry of Healthcare of Russian Federation; Neurobiology Department Research Center for Genetics and Life Sciences,
Sirius University of Science and Technology; Institute of Translational Biomedicine, St. Petersburg State University

Email: avkalueff@gmail.com
Russia, St. Petersburg; Russia, Sirius Federal Territory; Russia, St. Petersburg

M. M. Kotova

Neurobiology Department Research Center for Genetics and Life Sciences,
Sirius University of Science and Technology

Email: avkalueff@gmail.com
Russia, Sirius Federal Territory

N. P. Ilyin

World-class Scientific Research Center “Center of Personalized Medicine”,
Almazov National Medical Research Center Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University

Email: avkalueff@gmail.com
Russia, St. Petersburg; Russia, St. Petersburg

T. O. Kolesnikova

Neurobiology Department Research Center for Genetics and Life Sciences,
Sirius University of Science and Technology

Email: avkalueff@gmail.com
Russia, Sirius Federal Territory

D. S. Galstyan

World-class Scientific Research Center “Center of Personalized Medicine”,
Almazov National Medical Research Center Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University; Granov Russian Scientific Center for Radiology and Surgical Technologies,
Ministry of Healthcare of Russian Federation

Email: avkalueff@gmail.com
Russia, St. Petersburg; Russia, St. Petersburg; Russia, St. Petersburg

T. V. Vyunova

Institute of Molecular Genetics, National Research Center “Kurchatov Institute”

Email: avkalueff@gmail.com
Russia, Moscow

E. V. Petersen

Moscow Institute of Physics and Technology

Email: avkalueff@gmail.com
Russia, Moscow

A.V. Kalueff

World-class Scientific Research Center “Center of Personalized Medicine”,
Almazov National Medical Research Center Ministry of Healthcare of Russian Federation; Neurobiology Department Research Center for Genetics and Life Sciences,
Sirius University of Science and Technology; Institute of Translational Biomedicine, St. Petersburg State University; Granov Russian Scientific Center for Radiology and Surgical Technologies,
Ministry of Healthcare of Russian Federation; Ural Federal University

Author for correspondence.
Email: avkalueff@gmail.com
Russia, St. Petersburg; Russia, Sirius Federal Territory; Russia, St. Petersburg; Russia, St. Petersburg; Russia, Yekaterinburg

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Согласие на обработку персональных данных с помощью сервиса «Яндекс.Метрика»

1. Я (далее – «Пользователь» или «Субъект персональных данных»), осуществляя использование сайта https://journals.rcsi.science/ (далее – «Сайт»), подтверждая свою полную дееспособность даю согласие на обработку персональных данных с использованием средств автоматизации Оператору - федеральному государственному бюджетному учреждению «Российский центр научной информации» (РЦНИ), далее – «Оператор», расположенному по адресу: 119991, г. Москва, Ленинский просп., д.32А, со следующими условиями.

2. Категории обрабатываемых данных: файлы «cookies» (куки-файлы). Файлы «cookie» – это небольшой текстовый файл, который веб-сервер может хранить в браузере Пользователя. Данные файлы веб-сервер загружает на устройство Пользователя при посещении им Сайта. При каждом следующем посещении Пользователем Сайта «cookie» файлы отправляются на Сайт Оператора. Данные файлы позволяют Сайту распознавать устройство Пользователя. Содержимое такого файла может как относиться, так и не относиться к персональным данным, в зависимости от того, содержит ли такой файл персональные данные или содержит обезличенные технические данные.

3. Цель обработки персональных данных: анализ пользовательской активности с помощью сервиса «Яндекс.Метрика».

4. Категории субъектов персональных данных: все Пользователи Сайта, которые дали согласие на обработку файлов «cookie».

5. Способы обработки: сбор, запись, систематизация, накопление, хранение, уточнение (обновление, изменение), извлечение, использование, передача (доступ, предоставление), блокирование, удаление, уничтожение персональных данных.

6. Срок обработки и хранения: до получения от Субъекта персональных данных требования о прекращении обработки/отзыва согласия.

7. Способ отзыва: заявление об отзыве в письменном виде путём его направления на адрес электронной почты Оператора: info@rcsi.science или путем письменного обращения по юридическому адресу: 119991, г. Москва, Ленинский просп., д.32А

8. Субъект персональных данных вправе запретить своему оборудованию прием этих данных или ограничить прием этих данных. При отказе от получения таких данных или при ограничении приема данных некоторые функции Сайта могут работать некорректно. Субъект персональных данных обязуется сам настроить свое оборудование таким способом, чтобы оно обеспечивало адекватный его желаниям режим работы и уровень защиты данных файлов «cookie», Оператор не предоставляет технологических и правовых консультаций на темы подобного характера.

9. Порядок уничтожения персональных данных при достижении цели их обработки или при наступлении иных законных оснований определяется Оператором в соответствии с законодательством Российской Федерации.

10. Я согласен/согласна квалифицировать в качестве своей простой электронной подписи под настоящим Согласием и под Политикой обработки персональных данных выполнение мною следующего действия на сайте: https://journals.rcsi.science/ нажатие мною на интерфейсе с текстом: «Сайт использует сервис «Яндекс.Метрика» (который использует файлы «cookie») на элемент с текстом «Принять и продолжить».