Молекулярно-генетические механизмы регуляции циркадных ритмов и их роль в психопатологиях

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Аннотация

Циркадные (циркадианные) ритмы представляют собой циклические колебания интенсивности биологических процессов, связанные со сменой дня и ночи, к которым в ходе эволюции приспособились многие живые организмы. Нарушения циркадных ритмов провоцируются как факторами среды (смена часового пояса или продолжительности дня и ночи), так и поломками во внутренней регуляции циклов (мутации ключевых “часовых” генов). Эти изменения могут приводить к патогенезу различных заболеваний, в том числе психопатологий. Поскольку механизмы, лежащие в основе циркадной регуляции, достаточно консервативны, для большего понимания этих процессов и их связи с психопатологиями активно используют экспериментальные модели in vivo. В настоящем обзоре рассмотрены вопросы регуляции циркадных ритмов, а также их межтаксонные сходства и различия у млекопитающих и костных рыб (на примере широко используемых в биомедицине рыб зебраданио, Danio rerio). В работе обсуждаются современные представления о молекулярно-генетических механизмах, лежащих в основе регуляции циркадных ритмов, и их взаимосвязь с патогенезом психических расстройств у человека и модельных организмов.

Об авторах

К. В. Смирнова

Научно-исследовательский институт нейронаук и медицины; Новосибирский государственный университет

Автор, ответственный за переписку.
Email: vedelina@mail.ru
Россия, Новосибирск; Россия, Новосибирск

Н. Д. Чижова

Научно-исследовательский институт нейронаук и медицины; Новосибирский государственный университет

Email: amstislavskayatg@neuronm.ru
Россия, Новосибирск; Россия, Новосибирск

Е. В. Герасимова

Научно-технологический университет “Сириус”

Email: amstislavskayatg@neuronm.ru
Россия, Сочи

А. В. Калуев

Научно-исследовательский институт нейронаук и медицины; Новосибирский государственный университет; Научно-технологический университет “Сириус”; Санкт-Петербургский государственный университет; Уральский федеральный университет; Национальный медицинский исследовательский центр им. В.А. Алмазова МЗ РФ

Email: amstislavskayatg@neuronm.ru
Россия, Новосибирск; Россия, Новосибирск; Россия, Сочи; Россия, Санкт-Петербург; Россия, Екатеринбург; Россия, Санкт-Петербург

Т. Г. Амстиславская

Научно-исследовательский институт нейронаук и медицины; Новосибирский государственный университет

Автор, ответственный за переписку.
Email: amstislavskayatg@neuronm.ru
Россия, Новосибирск; Россия, Новосибирск

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