ПЛЮРИПОТЕНТНОСТЬ И ПЕРСПЕКТИВЫ КЛЕТОЧНЫХ ТЕХНОЛОГИЙ
- Авторы: Ерофеева Е.Д.1, Абдыев В.К.2, Еремеев А.В.2,3, Воротеляк Е.А.2,1, Васильев А.В.2,1
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Учреждения:
- Биологический факультет Московского государственного университета имени М.В. Ломоносова
- Институт биологии развития им. Н.К. Кольцова РАН
- Федеральный научно-клинический центр физико-химической медицины им. Ю.М. Лопухина ФМБА России
- Выпуск: Том 93, № 9 (2023)
- Страницы: 886-894
- Раздел: ТЕМАТИЧЕСКИЙ ВЫПУСК ПО БИОЛОГИИ
- URL: https://journals.rcsi.science/0869-5873/article/view/229402
- DOI: https://doi.org/10.31857/S0869587323090062
- EDN: https://elibrary.ru/IOTAJY
- ID: 229402
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Аннотация
Биология плюрипотентности – это современная область биологической науки, и одновременно инструмент для моделирования морфогенеза человека in vitro. Плюрипотентность – это свойство клеток самообновляться и дифференцироваться во все типы клеток взрослого организма, которое образуется в раннем эмбриогенезе у млекопитающих. Плюрипотентные стволовые клетки (ПСК) имеют в принципе безграничный потенциал в регенеративной и трансляционной медицине, открывая возможности лечения множества заболеваний, в том числе наследственных. В обзоре описаны характерные черты ПСК, моделирование раннего морфогенеза человека in vitro в бластоцисто-подобных структурах и гаструлоидах, моделирование органогенеза в органоидах. Рассмотрены примеры применения ПСК в регенеративной медицине и его риски. ПСК – это один из ключевых объектов современной клеточной биологии. Однако клиническое использование ПСК еще находится на стадии разработок и требует дальнейшего исследования для безопасного и эффективного применения.
Об авторах
Е. Д. Ерофеева
Биологический факультет Московского государственного университета имени М.В. Ломоносова
Email: vestnik.ran@yandex.ru
Россия, Москва
В. К. Абдыев
Институт биологии развития им. Н.К. Кольцова РАН
Email: vestnik.ran@yandex.ru
Россия, Москва
А. В. Еремеев
Институт биологии развития им. Н.К. Кольцова РАН; Федеральный научно-клинический центр физико-химической медицины им. Ю.М. Лопухина ФМБА России
Email: vestnik.ran@yandex.ru
Россия, Москва; Россия,
Москва
Е. А. Воротеляк
Институт биологии развития им. Н.К. Кольцова РАН; Биологический факультет Московского государственного университета имени М.В. Ломоносова
Email: vestnik.ran@yandex.ru
Россия, Москва; Россия, Москва
А. В. Васильев
Институт биологии развития им. Н.К. Кольцова РАН; Биологический факультет Московского государственного университета имени М.В. Ломоносова
Автор, ответственный за переписку.
Email: vestnik.ran@yandex.ru
Россия, Москва; Россия, Москва
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