Synthesis and Biological Activity of Esters Based on Cycloalkenedicarboxylic Acids
- 作者: Firstova A.1, Kofanov E.1, Kovaleva M.2
-
隶属关系:
- Yaroslavl State Technical University
- Yaroslavl State University named after P.G. Demidov
- 期: 卷 49, 编号 2 (2023)
- 页面: 153-164
- 栏目: Articles
- URL: https://journals.rcsi.science/0132-3423/article/view/145875
- DOI: https://doi.org/10.31857/S0132342323010086
- EDN: https://elibrary.ru/GHIOTR
- ID: 145875
如何引用文章
详细
Previously undescribed esters based on N-substituted imides of cycloaliphatic carboxylic acids have been synthesized in high yields and efficient methods for their preparation have been presented. Toxicological studies of the obtained compounds were carried out using various test objects (Chlorella vulgaris, Allium cepa, Drosophila melanogaster). It was shown that the studied compounds are not active against D. melanogaster, increase the frequency of mutations in C. vulgaris and have the ability to induce chromosomal rearrangements in A. cepa. The synthesized compounds can be used in the development of antitumor drugs.
作者简介
A. Firstova
Yaroslavl State Technical University
编辑信件的主要联系方式.
Email: firstova.a.a@mail.ru
Russia, 150023, Yaroslavl, Moskovsky prosp. 88
E. Kofanov
Yaroslavl State Technical University
Email: firstova.a.a@mail.ru
Russia, 150023, Yaroslavl, Moskovsky prosp. 88
M. Kovaleva
Yaroslavl State University named after P.G. Demidov
Email: firstova.a.a@mail.ru
Russia, 150003, Yaroslavl, ul. Sovetskaya 14
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