“Double Punch”: Hepatitis C in Patients with Genetic Defects of Iron Metabolism
- Authors: Danilenko N.G.1, Siniauskaya M.G.1, Lukashyk S.P.2, Karpov I.A.2, Davydenko O.G.1
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Affiliations:
- Institute of Genetics and Cytology, National Academy of Sciences of Belarus
- Belarusian State Medical University
- Issue: Vol 53, No 5 (2019)
- Pages: 407-417
- Section: Article
- URL: https://journals.rcsi.science/0095-4527/article/view/174143
- DOI: https://doi.org/10.3103/S0095452719050062
- ID: 174143
Cite item
Abstract
The review is focused on the development of chronic viral hepatitis C in patients with a genetic defect in the hereditary hemochromatosis (HFE) gene that controls iron metabolism. The effect of HFE gene mutations on the patient’s susceptibility to viral attack, the development of pathological processes in the liver, including the most severe complications, such as liver cirrhosis and hepatocellular carcinoma in chronic viral hepatitis C, and responsiveness of patients carrying the mutations to the treatment of viral hepatitis C are discussed.
About the authors
N. G. Danilenko
Institute of Genetics and Cytology, National Academy of Sciences of Belarus
Author for correspondence.
Email: cytoplasmic@mail.ru
Belarus, Minsk, 220072
M. G. Siniauskaya
Institute of Genetics and Cytology, National Academy of Sciences of Belarus
Email: svetlanalukashik@mail.ru
Belarus, Minsk, 220072
S. P. Lukashyk
Belarusian State Medical University
Author for correspondence.
Email: svetlanalukashik@mail.ru
Belarus, Minsk, 220116
I. A. Karpov
Belarusian State Medical University
Email: svetlanalukashik@mail.ru
Belarus, Minsk, 220116
O. G. Davydenko
Institute of Genetics and Cytology, National Academy of Sciences of Belarus
Email: svetlanalukashik@mail.ru
Belarus, Minsk, 220072