Synthesis, Immunomodulating and Antitumor Activities of Copolymers of Dialkylaminoethyl Methacrylates and Vinylsaccharides
- 作者: Nazarova O.1, Potapenkova L.2, Stukov A.2, Zolotova Y.1, Zhuravskaya O.1, Nekrasova T.1, Panarin E.1,3
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隶属关系:
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
- Peter the Great St. Petersburg Polytechnic University
- 期: 卷 51, 编号 4 (2017)
- 页面: 245-249
- 栏目: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244555
- DOI: https://doi.org/10.1007/s11094-017-1591-6
- ID: 244555
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详细
Water-soluble random copolymers of N,N-(dimethylamino)ethyl methacrylate or N,N-(diethylamino)ethyl methacrylate with vinylsaccharides (N-methacryloyl aminoglucose, 3-O-methacryloyl glucose, 1-O-methacryloyl sorbose) were synthesized. The copolymers differed in composition, structure of the carbohydrate fragment, and type of carbohydrate–main-polymer-chain bonds. The immunomodulating activity and antitumor properties of the synthesized copolymers were established. Copolymers containing sorbose residues possessed the most pronounced immunodepressant properties.
作者简介
O. Nazarova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
俄罗斯联邦, 31 Bol’shoi Prosp., St. Petersburg, 199004
L. Potapenkova
N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
Email: stukov2008@yandex.ru
俄罗斯联邦, 68 Leningradskaya St., Pesochnyi, St. Petersburg, 197758
A. Stukov
N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
编辑信件的主要联系方式.
Email: stukov2008@yandex.ru
俄罗斯联邦, 68 Leningradskaya St., Pesochnyi, St. Petersburg, 197758
Yu. Zolotova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
俄罗斯联邦, 31 Bol’shoi Prosp., St. Petersburg, 199004
O. Zhuravskaya
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
俄罗斯联邦, 31 Bol’shoi Prosp., St. Petersburg, 199004
T. Nekrasova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
俄罗斯联邦, 31 Bol’shoi Prosp., St. Petersburg, 199004
E. Panarin
Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
Email: stukov2008@yandex.ru
俄罗斯联邦, 31 Bol’shoi Prosp., St. Petersburg, 199004; 29 Politekhnicheskaya St., St. Petersburg, 195251