Synthesis, Immunomodulating and Antitumor Activities of Copolymers of Dialkylaminoethyl Methacrylates and Vinylsaccharides
- Авторлар: Nazarova O.1, Potapenkova L.2, Stukov A.2, Zolotova Y.1, Zhuravskaya O.1, Nekrasova T.1, Panarin E.1,3
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Мекемелер:
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
- Peter the Great St. Petersburg Polytechnic University
- Шығарылым: Том 51, № 4 (2017)
- Беттер: 245-249
- Бөлім: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244555
- DOI: https://doi.org/10.1007/s11094-017-1591-6
- ID: 244555
Дәйексөз келтіру
Аннотация
Water-soluble random copolymers of N,N-(dimethylamino)ethyl methacrylate or N,N-(diethylamino)ethyl methacrylate with vinylsaccharides (N-methacryloyl aminoglucose, 3-O-methacryloyl glucose, 1-O-methacryloyl sorbose) were synthesized. The copolymers differed in composition, structure of the carbohydrate fragment, and type of carbohydrate–main-polymer-chain bonds. The immunomodulating activity and antitumor properties of the synthesized copolymers were established. Copolymers containing sorbose residues possessed the most pronounced immunodepressant properties.
Авторлар туралы
O. Nazarova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Ресей, 31 Bol’shoi Prosp., St. Petersburg, 199004
L. Potapenkova
N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
Email: stukov2008@yandex.ru
Ресей, 68 Leningradskaya St., Pesochnyi, St. Petersburg, 197758
A. Stukov
N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: stukov2008@yandex.ru
Ресей, 68 Leningradskaya St., Pesochnyi, St. Petersburg, 197758
Yu. Zolotova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Ресей, 31 Bol’shoi Prosp., St. Petersburg, 199004
O. Zhuravskaya
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Ресей, 31 Bol’shoi Prosp., St. Petersburg, 199004
T. Nekrasova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Ресей, 31 Bol’shoi Prosp., St. Petersburg, 199004
E. Panarin
Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
Email: stukov2008@yandex.ru
Ресей, 31 Bol’shoi Prosp., St. Petersburg, 199004; 29 Politekhnicheskaya St., St. Petersburg, 195251