Synthesis, Immunomodulating and Antitumor Activities of Copolymers of Dialkylaminoethyl Methacrylates and Vinylsaccharides
- Авторы: Nazarova O.1, Potapenkova L.2, Stukov A.2, Zolotova Y.1, Zhuravskaya O.1, Nekrasova T.1, Panarin E.1,3
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Учреждения:
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
- Peter the Great St. Petersburg Polytechnic University
- Выпуск: Том 51, № 4 (2017)
- Страницы: 245-249
- Раздел: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244555
- DOI: https://doi.org/10.1007/s11094-017-1591-6
- ID: 244555
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Аннотация
Water-soluble random copolymers of N,N-(dimethylamino)ethyl methacrylate or N,N-(diethylamino)ethyl methacrylate with vinylsaccharides (N-methacryloyl aminoglucose, 3-O-methacryloyl glucose, 1-O-methacryloyl sorbose) were synthesized. The copolymers differed in composition, structure of the carbohydrate fragment, and type of carbohydrate–main-polymer-chain bonds. The immunomodulating activity and antitumor properties of the synthesized copolymers were established. Copolymers containing sorbose residues possessed the most pronounced immunodepressant properties.
Об авторах
O. Nazarova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Россия, 31 Bol’shoi Prosp., St. Petersburg, 199004
L. Potapenkova
N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
Email: stukov2008@yandex.ru
Россия, 68 Leningradskaya St., Pesochnyi, St. Petersburg, 197758
A. Stukov
N. N. Petrov Research Institute of Oncology, Ministry of Public Health of the Russian Federation
Автор, ответственный за переписку.
Email: stukov2008@yandex.ru
Россия, 68 Leningradskaya St., Pesochnyi, St. Petersburg, 197758
Yu. Zolotova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Россия, 31 Bol’shoi Prosp., St. Petersburg, 199004
O. Zhuravskaya
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Россия, 31 Bol’shoi Prosp., St. Petersburg, 199004
T. Nekrasova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: stukov2008@yandex.ru
Россия, 31 Bol’shoi Prosp., St. Petersburg, 199004
E. Panarin
Institute of Macromolecular Compounds, Russian Academy of Sciences; Peter the Great St. Petersburg Polytechnic University
Email: stukov2008@yandex.ru
Россия, 31 Bol’shoi Prosp., St. Petersburg, 199004; 29 Politekhnicheskaya St., St. Petersburg, 195251