Synthesis and Analgesic Activity of 1-substituted 3-methyl-6-methoxy-7(n-butoxy)-3,4-dihydroisoquinolines
- 作者: Surikova O.1, Yusov A.1, Makhmudov R.2, Mikhailovskii A.1
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隶属关系:
- Perm State Pharmaceutical Academy
- Perm State Science Research Institute University
- 期: 卷 51, 编号 1 (2017)
- 页面: 18-21
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244496
- DOI: https://doi.org/10.1007/s11094-017-1549-8
- ID: 244496
如何引用文章
详细
Cyclocondensation of O-butylated eugenol with various nitriles was used to synthesize 1-substituted derivatives of 3-methyl-6-methoxy-7-(n-butoxy)-3,4-dihydroisoquinoline. Hydrochlorides of the study compounds were tested for analgesic activity using the “hot plate” test. The experiments showed that the study compounds had analgesic effects greater than those of metamizole sodium and similar to those of ibuprofen.
作者简介
O. Surikova
Perm State Pharmaceutical Academy
Email: chem@folium.ru
俄罗斯联邦, Perm
A. Yusov
Perm State Pharmaceutical Academy
Email: chem@folium.ru
俄罗斯联邦, Perm
R. Makhmudov
Perm State Science Research Institute University
Email: chem@folium.ru
俄罗斯联邦, Perm
A. Mikhailovskii
Perm State Pharmaceutical Academy
Email: chem@folium.ru
俄罗斯联邦, Perm