Synthesis and Analgesic Activity of 1-substituted 3-methyl-6-methoxy-7(n-butoxy)-3,4-dihydroisoquinolines
- Авторы: Surikova O.1, Yusov A.1, Makhmudov R.2, Mikhailovskii A.1
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Учреждения:
- Perm State Pharmaceutical Academy
- Perm State Science Research Institute University
- Выпуск: Том 51, № 1 (2017)
- Страницы: 18-21
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244496
- DOI: https://doi.org/10.1007/s11094-017-1549-8
- ID: 244496
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Аннотация
Cyclocondensation of O-butylated eugenol with various nitriles was used to synthesize 1-substituted derivatives of 3-methyl-6-methoxy-7-(n-butoxy)-3,4-dihydroisoquinoline. Hydrochlorides of the study compounds were tested for analgesic activity using the “hot plate” test. The experiments showed that the study compounds had analgesic effects greater than those of metamizole sodium and similar to those of ibuprofen.
Об авторах
O. Surikova
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Россия, Perm
A. Yusov
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Россия, Perm
R. Makhmudov
Perm State Science Research Institute University
Email: chem@folium.ru
Россия, Perm
A. Mikhailovskii
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Россия, Perm