Synthesis and Analgesic Activity of 1-substituted 3-methyl-6-methoxy-7(n-butoxy)-3,4-dihydroisoquinolines
- Authors: Surikova O.V.1, Yusov A.S.1, Makhmudov R.R.2, Mikhailovskii A.G.1
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Affiliations:
- Perm State Pharmaceutical Academy
- Perm State Science Research Institute University
- Issue: Vol 51, No 1 (2017)
- Pages: 18-21
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244496
- DOI: https://doi.org/10.1007/s11094-017-1549-8
- ID: 244496
Cite item
Abstract
Cyclocondensation of O-butylated eugenol with various nitriles was used to synthesize 1-substituted derivatives of 3-methyl-6-methoxy-7-(n-butoxy)-3,4-dihydroisoquinoline. Hydrochlorides of the study compounds were tested for analgesic activity using the “hot plate” test. The experiments showed that the study compounds had analgesic effects greater than those of metamizole sodium and similar to those of ibuprofen.
About the authors
O. V. Surikova
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm
A. S. Yusov
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm
R. R. Makhmudov
Perm State Science Research Institute University
Email: chem@folium.ru
Russian Federation, Perm
A. G. Mikhailovskii
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm