Synthesis and Hypotensive Activity of Novel Styryl Derivatives Based on Ethyl-4-(4-Methoxyphenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate

S. D. Fazylov; O. A. Nurkenov; T. S. Zhivotova; A. E. Arinova; I. S. Tolepbek; A. N. Zhakupova; R. E. Bakirova; L. E. Muravleva

doi:10.1007/s11094-016-1466-2

Synthesis and Hypotensive Activity of Novel Styryl Derivatives Based on Ethyl-4-(4-Methoxyphenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate

作者: Fazylov S.¹, Nurkenov O.¹, Zhivotova T.¹, Arinova A.¹, Tolepbek I.¹, Zhakupova A.¹, Bakirova R.², Muravleva L.²
隶属关系:
1. Institute of Organic Synthesis and Carbochemistry
2. Karaganda State Medical University
期: 卷 50, 编号 7 (2016)
页面: 440-442
栏目: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244413
DOI: https://doi.org/10.1007/s11094-016-1466-2
ID: 244413

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详细

Three-component condensation of thiourea, ethyl acetoacetic ester, and anisaldehyde was performed to synthesize ethyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. This compound interacted with aromatic aldehydes to yield the corresponding styryl derivatives. The hypotensive activity of the compounds synthesized here was assessed.