Synthesis and Hypotensive Activity of Novel Styryl Derivatives Based on Ethyl-4-(4-Methoxyphenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
- Authors: Fazylov S.D.1, Nurkenov O.A.1, Zhivotova T.S.1, Arinova A.E.1, Tolepbek I.S.1, Zhakupova A.N.1, Bakirova R.E.2, Muravleva L.E.2
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Affiliations:
- Institute of Organic Synthesis and Carbochemistry
- Karaganda State Medical University
- Issue: Vol 50, No 7 (2016)
- Pages: 440-442
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244413
- DOI: https://doi.org/10.1007/s11094-016-1466-2
- ID: 244413
Cite item
Abstract
Three-component condensation of thiourea, ethyl acetoacetic ester, and anisaldehyde was performed to synthesize ethyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. This compound interacted with aromatic aldehydes to yield the corresponding styryl derivatives. The hypotensive activity of the compounds synthesized here was assessed.
About the authors
S. D. Fazylov
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Kazakhstan, Karaganda
O. A. Nurkenov
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Kazakhstan, Karaganda
T. S. Zhivotova
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Kazakhstan, Karaganda
A. E. Arinova
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Kazakhstan, Karaganda
I. S. Tolepbek
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Kazakhstan, Karaganda
A. N. Zhakupova
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Kazakhstan, Karaganda
R. E. Bakirova
Karaganda State Medical University
Email: chem@folium.ru
Kazakhstan, Karaganda
L. E. Muravleva
Karaganda State Medical University
Email: chem@folium.ru
Kazakhstan, Karaganda