Synthesis and Hypotensive Activity of Novel Styryl Derivatives Based on Ethyl-4-(4-Methoxyphenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
- Авторы: Fazylov S.1, Nurkenov O.1, Zhivotova T.1, Arinova A.1, Tolepbek I.1, Zhakupova A.1, Bakirova R.2, Muravleva L.2
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Учреждения:
- Institute of Organic Synthesis and Carbochemistry
- Karaganda State Medical University
- Выпуск: Том 50, № 7 (2016)
- Страницы: 440-442
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244413
- DOI: https://doi.org/10.1007/s11094-016-1466-2
- ID: 244413
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Аннотация
Three-component condensation of thiourea, ethyl acetoacetic ester, and anisaldehyde was performed to synthesize ethyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate. This compound interacted with aromatic aldehydes to yield the corresponding styryl derivatives. The hypotensive activity of the compounds synthesized here was assessed.
Об авторах
S. Fazylov
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Казахстан, Karaganda
O. Nurkenov
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Казахстан, Karaganda
T. Zhivotova
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Казахстан, Karaganda
A. Arinova
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Казахстан, Karaganda
I. Tolepbek
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Казахстан, Karaganda
A. Zhakupova
Institute of Organic Synthesis and Carbochemistry
Email: chem@folium.ru
Казахстан, Karaganda
R. Bakirova
Karaganda State Medical University
Email: chem@folium.ru
Казахстан, Karaganda
L. Muravleva
Karaganda State Medical University
Email: chem@folium.ru
Казахстан, Karaganda