Мақаланы E-mail арқылы жіберу Synthesis and Antidepressant Properties of 2-[3-Methyl-7-(Thietanyl-3)-1-Ethylxanthinyl-8-Thio] Acetic Acid Hydrazides
- Авторлар: Valeeva L.A.1, Davlyatova G.G.1, Shabalina Y.V.1, Isakova A.V.1, Khaliullin F.A.1, Nikitina I.L.1
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Мекемелер:
- Bashkir State Medical University
- Шығарылым: Том 50, № 6 (2016)
- Беттер: 358-361
- Бөлім: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244394
- DOI: https://doi.org/10.1007/s11094-016-1451-9
- ID: 244394
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Аннотация
2-[3-Methyl-7-(thietanyl-3)-1-ethylxanthinyl-8-thio]acetic acid hydrazide was synthesized in two steps by our improved method. The structures of the synthesized compounds were confirmed by IR and NMR spectroscopic data. The acute toxicity was studied. The LD50 values were 700 mg/kg for outbred albino mice. Tail-suspension tests (TST) and forced swimming tests (FST) found that 2-[3-methyl-7-(thietanyl-3)-1-ethylxanthinyl-8-thio]acetic acid hydrazide exhibited antidepressant activity that was most pronounced at a dose of 12 mg/kg.
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Авторлар туралы
L. Valeeva
Bashkir State Medical University
Хат алмасуға жауапты Автор.
Email: bsmu.pharmacology2@yandex.ru
Ресей, 3 Lenina St., Ufa, Bashkortostan, 450000
G. Davlyatova
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Ресей, 3 Lenina St., Ufa, Bashkortostan, 450000
Yu. Shabalina
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Ресей, 3 Lenina St., Ufa, Bashkortostan, 450000
A. Isakova
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Ресей, 3 Lenina St., Ufa, Bashkortostan, 450000
F. Khaliullin
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Ресей, 3 Lenina St., Ufa, Bashkortostan, 450000
I. Nikitina
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Ресей, 3 Lenina St., Ufa, Bashkortostan, 450000
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