Synthesis and Antidepressant Properties of 2-[3-Methyl-7-(Thietanyl-3)-1-Ethylxanthinyl-8-Thio] Acetic Acid Hydrazides
- Authors: Valeeva L.A.1, Davlyatova G.G.1, Shabalina Y.V.1, Isakova A.V.1, Khaliullin F.A.1, Nikitina I.L.1
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Affiliations:
- Bashkir State Medical University
- Issue: Vol 50, No 6 (2016)
- Pages: 358-361
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244394
- DOI: https://doi.org/10.1007/s11094-016-1451-9
- ID: 244394
Cite item
Abstract
2-[3-Methyl-7-(thietanyl-3)-1-ethylxanthinyl-8-thio]acetic acid hydrazide was synthesized in two steps by our improved method. The structures of the synthesized compounds were confirmed by IR and NMR spectroscopic data. The acute toxicity was studied. The LD50 values were 700 mg/kg for outbred albino mice. Tail-suspension tests (TST) and forced swimming tests (FST) found that 2-[3-methyl-7-(thietanyl-3)-1-ethylxanthinyl-8-thio]acetic acid hydrazide exhibited antidepressant activity that was most pronounced at a dose of 12 mg/kg.
Keywords
About the authors
L. A. Valeeva
Bashkir State Medical University
Author for correspondence.
Email: bsmu.pharmacology2@yandex.ru
Russian Federation, 3 Lenina St., Ufa, Bashkortostan, 450000
G. G. Davlyatova
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Russian Federation, 3 Lenina St., Ufa, Bashkortostan, 450000
Yu. V. Shabalina
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Russian Federation, 3 Lenina St., Ufa, Bashkortostan, 450000
A. V. Isakova
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Russian Federation, 3 Lenina St., Ufa, Bashkortostan, 450000
F. A. Khaliullin
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Russian Federation, 3 Lenina St., Ufa, Bashkortostan, 450000
I. L. Nikitina
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Russian Federation, 3 Lenina St., Ufa, Bashkortostan, 450000